主题：【原创】对所谓FDA三聚氰胺安全标准的分析 -- 小玩意

Melamine (>95 % pure) was given to groups of 50 male rats and 50 mice of each sex for

103 weeks via diets containing 2,250 or 4,500 mg/kg melamine. Groups of 50 female rats

were fed diets containing 4,500 or 9,000 mg/kg melamine. Transitional-cell carcinomas

were found in the urinary bladder of male rats (controls, 0/45; low dose, 0/50; high-dose,

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8/49 (16 %)). These tumors were not observed in female rats. Seven of the eight highdose

male rats with the transitional-cell carcinomas also had bladder stones (NTP, 1983).

Although bladder tumors related to calculi formation are not considered to be speciesspecific,

they are related to the administration of high doses (IARC, 1999; Meek, 2003).