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主题:【原创】在西西河“求实” -- landlord

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家园 【记录】关于方舟子的专利

看到河友渡泸的一个求实贴,宝推了一把

看到他驳斥“Biotechnology company”那一条,我也是觉着啼笑皆非。那位造谣的实在是缺乏常识,不过居然还有人信,看来蒙人还真不难。当然,想蒙所有的人就太难了

又看到底下有个帖子自以为是:查不到方舟子的专利(那位转造谣贴的理所当然的送了花,嘿嘿)。我也去美国专利局查了一把,结果如下:United States Patent 6,284,456

United States Patent 6,284,456

Jones , et al. September 4, 2001

Transcriptional coactivator that interacts with Tat protein and regulates its binding to TAR RNA, methods for modulating Tat transactivation, and uses therefor

Abstract

In accordance with the present invention, isolated nucleic acid encoding a host cell protein that regulates Tat transactivation has been discovered. The protein is the first discovered constituent of the TAK/TEFb complex which associates with the HIV Tat, via divalent cation metals, and is necessary for the binding of Tat to TAR RNA. This protein, cyclin T1, is an 87 kDa cyclin partner for the PITALRE kinase. It is further discovered that Tat must interact with TAK in order to bind to TAR RNA with affinity and with the appropriate sequence specificity that is observed in vivo. In accordance with another aspect of the invention, formulations useful for modulation of Tat transactivation have been developed. In addition, assays have been developed for the identification of compounds useful to modulate the above-described processes.

Inventors: Jones; Katherine A. (Encinitas, CA), Wei; Ping (San Diego, CA), Garber; Mitchell (Woodland Hills, CA), Fang; Shi-Min (San Diego, CA)

Assignee: The Salk Institute for Biological Studies (La Jolla, CA)

Appl. No.: 09/476,482

Filed: December 30, 1999

大概花了5分钟吧,不算太难找

关键词(Tags): #求实#方舟子#专利通宝推:冰雪迎梅,
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