主题：【整理】黎阳：为肖传国说句公道话（一个海归的杯具） -- 迷途笨狼

Open letter in support of Chuan-Guo Xiao, M.D. from the International Academic Community

September 29, 2010

To all:

We have all had the pleasure of knowing Dr. Chuan-Guo Xiao for many years. He is an internationally respected surgeon-scientist who has made major advances in the development of neuroregeneration to restore voiding and bowel function. Dr. Xiao performed groundbreaking animal research in the United States, demonstrating that a motor nerve that innervates the leg can be used to reinnervate the bladder and bowel. This reinnervation allows for development of a reflex to initiate bladder function. The results of his studies were published in peer-reviewed journals and other scientists have replicated Xiao’s findings confirming these results.

Dr. Xiao eventually took the courageous step of moving from animal research to human studies and began performing the rerouting procedure on patients with spinal cord injury and spina bifida in China.

Neurogenic bladder is life threatening in China due to a lack of both antimuscarinics and intermittent catheterization, and lessening the complications of neurogenic bladder would be considered a lifesaving success. Patients with neurogenic bladder and bowel suffer greatly and endure a host of issues such as urinary retention, incontinence, recurrent infections, renal insufficiency, fecal incontinence, constipation, and poor quality of life. For a procedure as complicated as nerve rerouting requiring nerve regeneration, one cannot expect normalization of bladder and bowel function to be the definition of success. What is important is that the benefits outweigh the risks of the procedure.

Dr. Xiao published his clinical results in peer-reviewed journals and was twice honored by the Jack Lapides Essay Contest, one of the most respected international awards given to scientists who make major contributions to the field of neurourology. In 2008, he was named the Kelm Hjalmas Memorial Lecturer from the International Children’s Continence Society for his scientific achievements. Many of us have traveled to China to examine patients treated by Dr. Xiao and/or have been trained by him in the nerve rerouting surgery he invented. Dr. Xiao is a very skilled surgeon who is passionate about patient care and works tirelessly to train physicians around the world in performing his nerve rerouting procedure.

In the United States, an independent and very rigorous pilot research trial was performed to test the safety and efficacy of this procedure. The one-year results were recently published in the Journal of Urology. At the 12-month follow-up visit, a cutaneous to bladder reflex was found in 7 of 9 spina bifida patients, confirming that rerouting does occur. This finding by itself is remarkable and Dr. Xiao should be commended. In addition, a number of patients demonstrated improvement in bladder and bowel function, which has continued to improve with longer patient follow-up. The 36-month results are currently being analyzed and will be reported in the near future. The pilot data was supportive of Dr. Xiao’s procedure, and now an NIH sponsored clinical trial is being conducted to further study lumbar to sacral nerve rerouting in spina bifida patients. In addition, similar procedures have been done worldwide, with Dr. Xiao helping to mentor the surgeons at each site.

The Chinese people and government should be proud of Dr. Xiao for his dedication to his patients, his scientific achievements, and his willingness to train doctors around the world how to perform his surgery. The International scientific community was shocked to hear of Dr. Xiao’s arrest. Those of us who know Dr. Xiao well find it difficult to believe that he is involved in these attacks.

Dr. Xiao is a compassionate man who is respected worldwide for his integrity and his innovative scientific contributions to society. We implore the Chinese government and authorities to treat Dr. Xiao fairly and to protect his human rights as these charges are investigated. Please strongly consider Dr. Xiao’s scientific and humanitarian contributions to the world as facts are gathered in this case.

Sincerely,

Kenneth M. Peters, MD

Professor and Chairman of Urology

Beaumont Hospital

Royal Oak, Michigan

Jack S. Elder, M.D.

Chief of Urology, Henry Ford Health System

Associate Director, Vattikuti Urology Institute

Department of Urology, Children's Hospital of Michigan

Clinical Professor of Urology, Case School of Medicine

Edwin A. Smith M.D.

Assistant Clinical Professor of Urology

Emory University School of Medicine

Atlanta, Georgia

Kevin M. Feber, MD, FAAP

Board Certified in Pediatric Urology

Comprehensive Urology

William Beaumont Children's Hospital

Ananias C. Diokno, M.D., F.A.C.S.Executive Vice President & CMOBeaumont HospitalRoyal Oak, Michigan 48073 USA

Juan José de Benito

Urologist

Hospital Nacional de Clínicas

Córdoba, Argentina.

William E. Nantau B.Sc., CNIMClinical ManagerClinical Neurophysiology DepartmentBeaumont Hospital Royal Oak

Evan J Kass MD,FACS,FAAPChief, Division of Pediatric UrologyBeaumont Childrens HospitalProfessor of Urology, Oakland University-William Beaumont School of Medicine

Jacques Corcos MD.Professor of Urology, McGill UniversityGeneral Secretary of the International Continence SocietyJewish General hospital3755 Cote Ste-CatherineMontreal, Quebec, Canada H3T 1E2

Jose Gonzalez, M.D.

Department of Urology

Beaumont Hospital

Royal Oak, Michigan

Christopher Payne, MD

Associate Professor of Urology

Stanford University Medical School

Stanford, CA 94305-5118

Kenneth I. Glassberg, MD

Director, Division of Pediatric Urology

Morgan Stanley Children's Hospital of New York-Presbyterian

Professor of Urology, Columbia University

College of Physicians and Surgeons

3959 Broadway, CHN 1118

Earl Y. Cheng, MD

Associate Professor of Urology

Children’s Memorial Hospital

Chicago, Illinois

Darius J. Bagli, MDCM

Professor of Surgery

Senior Associate Scientist

Director of Urology Research

Divisions of Urology and

Developmental & Stem Cell Biology

The Hospital For Sick Children

Institute of Medical Science

University of Toronto

Henri B. LOTTMANN, MD, FEBU, FEBPS, FRCS(england) FEBPU

Paediatric urology unit

Hopital Necker-Enfants-Malades

149, rue de Sèvres

75015 Paris

France

Dr. Amrish Vaidya MS. MCh.Consultant Paediatric Surgeon,Kokilaben Dhirubhai Ambani Hospital,4 Bungalows, Andheri W, Mumbai, India

Marc Cendron, MD

Associate Professor in Urology

Harvard Medical School

Children’s Hospital Boston

Boston, MA

Stuart B. Bauer, MD

Associate Director, Neurourology

Professor of Urology

Harvard Medical School

Children’s Hospital Boston

Boston, MA

Edmond T. Gonzales, Jr., MD

Professor of Urology

Baylor College of Medicine

Richard Macchia, MD FACS

SUNY Distinguished Teaching Professor

Cleveland Clinic, Florida

Benjamin Girdler, MD

Urology Center of the Rockies

Fort Collins, Colorado

William C. de Groat, Ph.D.

Professor of Pharmacology

University of Pittsburgh

Michael R. Ruggieri, Sr., Ph.D.

Director of Urologic Research

Temple University School of Medicine

Stanley J Kogan MDChief, Pediatric UrologyChildren's Hospital at MontefioreBronx NY USA

Anthony Caldamone, MD

University Urologic Associates, Inc.2 Dudley St Ste 185Providence, RI 02905

Yves Homsy MD, FRCSC, FAAP Clinical Professor of Urological Surgery and Pediatrics University of South Florida Children's Urology Group 5507 E. Longboat Blvd Tampa FL 33615

Dr. Enrique Turina

Professor of urology of the National University of Buenos Aires

Chief of section Urology of Instituto de Rehabilitación

Government of Buenos Aires, Argentina.

Dr. Angel Ozón

Urologist of the Instituto de Rehabilitación of Buenos Aires

Dr. Daniel Ekizian

Urologist of Instituto de Rehabilitación.

Professor Dr. med. Karl-Dietrich Sievert

Vice Chair Prof. of Urology, Director - Uro-oncology, Neurourology, Incontinence, & Reconstructive Urology Department of Urology University of Tuebingen D72076 Tuebingen, Germany

Holly Gilmer, MD

Chief of Pediatric Neurosurgery

Beaumont Hospital

Royal Oak, Michigan

Yegappan Lakshmanan, MD

Chief, Pediatric Urology

Children’s Hospital of Michigan