主题：【整理】上海抗疫摆烂的余响——巴黎贝甜事件 -- 乾道学派

https://pubmed.ncbi.nlm.nih.gov/8939440/

Mol Microbiol. 1996 Nov;22(3):583-92. doi: 10.1046/j.1365-2958.1996.00133.x.

Site-directed mutagenesis of the katG gene of Mycobacterium tuberculosis: effects on catalase-peroxidase activities and isoniazid resistance

D A Rouse 1, J A DeVito, Z Li, H Byer, S L Morris

"Rouse et al. validated this hypothesis in a well-designed

study that investigated the impact of specific

missense m

utations on KatG function. This was

accomplished by introducing fourteen genetically

defined mutations at thirteen different codons (36)."