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主题:【原创】对所谓FDA三聚氰胺安全标准的分析 -- 小玩意

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家园 请看原文,大鼠做出来的NOAEL是63mg/kg/day

外链出处

The point of departure (POD) is the NOAEL of 63 mg/kg/day from the rodent subchronic bioassay. This POD was then divided by two 10-fold safety/uncertainty factors (SF/UF) to account for inter- and intra-species sensitivity, for a total SF/UF of 100. The resulting Tolerable Daily Intake (TDI) is 0.63 mg/kg bw/day. The TDI is defined as the estimated maximum amount of an agent to which individuals in a population may be exposed daily over their lifetimes without an appreciable health risk with respect to the endpoint from which the NOAEL is calculated.

NOAEL=不会引起任何可观察负面作用的剂量

在大鼠身上每天63mg/kg以下的摄入量不会引起任何可观察的负面作用。FDA也知道这个数值直接套用在人身上并不保险,因此加入物种/个体差异安全因子(稀释10倍),未知因素安全因子(稀释10倍),推测出人的每日可容忍摄入量:

63mg/kg/day*0.1*0.1=0.63mg/kg/day

很多安全标准就是靠动物实验加上“以防万一”的安全因子推测出来的,毕竟FDA不可能拿活人来搞安全剂量试验。

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